![]() ![]() Recent data implicate dysregulated SATB1 expression in the pathogenesis of mycosis fungoides (MF), the most frequent variant of cutaneous T cell lymphoma (CTCL.) whereas increased SATB1 expression had the opposite effect indicating that the mir-155 target SATB1 is a repressor of IL-5 and IL-9 in malignant T cells. Special AT rich-binding1 protein ( SATB1) in malignant T cellsįredholm, Simon Willerslev-Olsen, Andreas Met, Özcanĭeficient expression of Suppressor Special AT-rich Binding-1 ( SATB1) hampers thymocyte development and results in inept T cell lineages. These results suggest that components accumulating within the phagosome rather than viable bacilli are responsible for the retention of CORO1A, and that there is also a bactericidal mechanism in the macrophage that might counter the effects of CORO1A leprae were difficult to detect by acid-fast staining. Moderate to strong CORO1A retention was observed in late lesions that contained foamy histiocytes, in which M. leprae, CORO1A recruitment from the plasma membrane to the phagosomal membrane was observed. ![]() When cultured macrophages were infected with M. leprae), where Toll-like receptor 2 was also visualized by immunostaining. In this study, we show that CORO1A strongly localizes on the membrane of phagosomes that contain Mycobacterium leprae (M. bovis BCG) infection, it was shown that the host protein, CORO1A, also known as tryptophan aspartate-containing coat protein (TACO), accumulates on the phagosomal membrane, resulting in inhibition of phagosome-lysosome fusion, and thus augmenting intracellular survival. In a study of Mycobacterium bovis Bacille Calmette-Guérin (M. To survive within the cell, mycobacteria must escape intracellular bactericidal mechanisms. Mycobacteria have acquired an intracellular lifestyle within the macrophage, which is best exemplified by the enlarged infected histiocytes seen in lepromatous leprosy. Suzuki, Koichi Takeshita, Fumihiko Nakata, Noboru Ishii, Norihisa Makino, Masahiko International Nuclear Information System (INIS) ![]() Localization of CORO1A in the Macrophages Containing Mycobacterium leprae ![]()
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